Polly asks Paolo if the number of lesions on the brain at the onset of MS indicate how aggressive it will be?
Studies have shown that the lesions load, number of lesions in a scan done early on does have a predictive effect on the course of MS. Now this has been shown to clearly differentiate people who are going to have benign versus non-benign MS, studies showing that people with more lesions are going to have an aggressive course have not been done so far, but there are studies, including our own, that show that people who have a higher number of relapses during the first year, during the first two years from onset, do have a higher risk to experience an aggressive course.
If those people were to take drugs very quickly, so to get Copaxone to not work and then get on to Tysabri in those first two years, would you say that that then reduces the risk of progression coming later?
I am convinced of that.
MS Reporter: Polly
MS Expert: Dr Paolo Muraro sees patients at Imperial College Healthcare NHS Trust, and his research programme is aimed at understanding and developing effective therapies for multiple sclerosis.