Last reply 1 month ago
Safety of Shingrix shingles vaccine

I am ineligible for the NHS shingles vaccination a) because I’m outside the age group it’s offered to and b) because it’s a live vaccine. I take fingolimod which means that all live vaccines are contraindicated. (I’m told that the jury’s out with regard to live vaccines for all MSers in any case.) So when I heard that a non-live shingles vaccine is now available privately I got interested – getting shingles on top of the MS would be the stuff of nightmares and any protection offered would be money well spent IMO. The worry would be that it could worsen the MS. The company’s blurb didn’t have much to say about its use with immuno-compromised patients so I decided to ask advice from the MS team. The neuro has replied, enclosing the evidence gathered from the hospital pharmacist’s (extensive) investigations into the drug trials. His advice is not to have the vaccination. When I see him next year I’ll ask further, but it’s looking like I can’t do anything to avoid the risk of shingles. I’ll post any updates on this.

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zulfihan
1 month ago

They asked for blood test and based on the i will get vaccinated,,, as I was advised to change to gilenya, so l am a bit concerned about the vaccination they are going to do to me. The question for me now is what lt really means to get vaccinated. Will it trigger the MS and the will have relapse.

What does live vaccine means?
Shingles (herpes zoster) vaccine: This live vaccine may be safe to have if you’ve had chickenpox and your body already “knows” the virus.
A practice advisory from the American Academy of Neurology (Rutschmann et al 2002) found strong evidence against an increased risk of MS exacerbation after influenza immunization.

Inactivated vaccines are generally considered safe for people with MS, including those who are taking an interferon medication (Avonex®, Betaseron®, Extavia®, Plegridy®, Rebif®), Aubagio®, Copaxone®, Gilenya®, Glatopa®, Lemtrada®, mitoxantrone, Tecfidera® or Tysabri®.
Live, attenuated vaccines are generally not recommended for a person with MS because their ability to cause disease has been weakened but not totally inactivated.


stumbler
1 month ago

cameron
1 month ago

@zulfihan – is it the live shingles vaccination you’re getting? You would certainly not be offered this once you’re on Gilenya. As I said, I’m told the jury’s out on whether live vaccines are totally safe for any MS patient. On the other hand, the prospect of avoiding the danger of shingles is an attractive one!


zulfihan
1 month ago

Hi Cameron,
There is considerable amount of information that suggests that live vaccination is not recommended, Cleveland published the paper and very clearly stated in that. i read yesterday. I gave blood and if i need i will get chicken pox vaccine which is also a live attenuated vaccine and not recommended.

Dr, suggested this vaccine before i go on to Gilenya again i do not know what to do?

Thanks


chezy17
1 month ago

I had the shingles vaccine and I felt fine after it, I needed to have it for my Cladribine.


chezy17
1 month ago

I’ve not I 🤦‍♀️


cameron
1 month ago

@zulfihan – there are three issues here. 1) Once on Gilenya, you DEFINITELY can’t have the NHS shingles vaccine, the yellow fever vaccine or any other vaccine that’s live. The only way you could would be to stop the Gilenya, have the vaccination then restart the Gilenya. Obviously that would be a really bad choice because you’d have to have the day in hospital again and in the meantime, having stopped the Gilenya the MS would likely flare. 2) Before you start the Gilenya, it does make sense therefore to get this live vaccine EXCEPT that there are concerns that it might upset the MS. It’s a risk but if your neuro is recommending it, perhaps you should ask him/her to quantify that risk. What are the known odds? and 3) the Shingrix vaccine isn’t live and so IN THEORY it shouldn’t be any riskier than other non-live vaccines e.g. the flu jab for an MSer. However, it’s my neuro’s advice that I shouldn’t have it, so I’ll abide by that. As far as I can see, it’s not been tested on MS patients so maybe that’s why the neuro isn’t recommending it. It’s a confusing picture, isn’t it!


zulfihan
1 month ago

I am currently on Avonex and he suggested to change. l am waiting to see the blood test . Afte thet l will talk to him, by the way l am ln Saudi Arabia and not so many DMTs are available here. l have doubt about the Dr. knowledge as far as the vaccines safety concerned. He is not MS specialist.

Thanks alot

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