Last reply 1 month ago
Remyelination sometime soon?

Hey there!

I’ve been recently diagnosed with PPMS, and still enjoy pretty good neurologic function.

I will be starting ocrelizumab in the coming months. Is it realistic to expect remyelination therapies sometime soon? Has anyone read any clinical trials, articles, etc regarding this kind of therapies and the progress being made in regards to reducing disability?

Also, why should PPMS and RRMS be different in regards to remyelination? There must be some difference in pathogenesis, but the resulting demyelination is quite similar, right? (besides location, probably…)

I am not a scientist, of course, but I’m just interested in how this disease works… :/

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fxms
1 month ago

Has anyone heard of a Phase II clinical trial with bexarotene??


nutshell88
1 month ago

I heard an egyptian doctor saying this moght herlp beans and corn germ
https://en.m.wikipedia.org/wiki/Choline
Im planning to start them but waiting to see my neuro


stumbler
1 month ago

@fxms , here’s some details about Bexarotene and the remyelinating trial:-

https://www.mstrust.org.uk/a-z/bexarotene


stumbler
1 month ago

And, here’s some details about Ocrelizumab :-

https://www.mstrust.org.uk/a-z/ocrelizumab-ocrevus


fxms
1 month ago

@stumbler I guess the results for the bexarotene trial have not been reported yet. At least I couldn’t find it.

I heard ocrelizumab can achieve mild recovery, but it’s not technically a remyelination therapy.

I guess we’ll have to wait until ECTRIMS 2018 for news on the progress of remyelination

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