Last reply 1 month ago
Remyelination sometime soon?

Hey there!

I’ve been recently diagnosed with PPMS, and still enjoy pretty good neurologic function.

I will be starting ocrelizumab in the coming months. Is it realistic to expect remyelination therapies sometime soon? Has anyone read any clinical trials, articles, etc regarding this kind of therapies and the progress being made in regards to reducing disability?

Also, why should PPMS and RRMS be different in regards to remyelination? There must be some difference in pathogenesis, but the resulting demyelination is quite similar, right? (besides location, probably…)

I am not a scientist, of course, but I’m just interested in how this disease works… :/

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fxms
3 months ago

Has anyone heard of a Phase II clinical trial with bexarotene??


nutshell88
3 months ago

I heard an egyptian doctor saying this moght herlp beans and corn germ
https://en.m.wikipedia.org/wiki/Choline
Im planning to start them but waiting to see my neuro


stumbler
3 months ago

@fxms , here’s some details about Bexarotene and the remyelinating trial:-

https://www.mstrust.org.uk/a-z/bexarotene


stumbler
3 months ago

And, here’s some details about Ocrelizumab :-

https://www.mstrust.org.uk/a-z/ocrelizumab-ocrevus


fxms
3 months ago

@stumbler I guess the results for the bexarotene trial have not been reported yet. At least I couldn’t find it.

I heard ocrelizumab can achieve mild recovery, but it’s not technically a remyelination therapy.

I guess we’ll have to wait until ECTRIMS 2018 for news on the progress of remyelination


chueykooh
1 month ago

This is the one I’ve been watching for several years now.
https://multiplesclerosisnewstoday.com/2017/10/25/msparis2017-interview-with-biogen-focused-on-opicinumab-an-anti-lingo-antibody/
The first trial didn’t go as hoped but they did notice it had more benefits when administered at a lower dose, so now they are doing new clinical trials.

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