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richmurray
3 years ago

Methanol (formaldehyde) toxicity, in humans only, comes from aspartame, cigarette wood peat smoke, fresh tomatoes, unfresh fruits and juices in cans and jars — WC Monte paradigm since 2007 — ADH1 enzyme forms free floating formaldehyde inside cells in 20 tissues: Rich Murray 2015.06.02
rmforall.blogspot.com/2015/06/methanol-formaldehyde-toxicity-in.html

Methanol is the plausible candidate toxin that initiates MS and many other chronic human ailments.

It circulates in the human bloodstream with half-life 3 hours, and so every minute readily enters every cell in the adult and fetus, to be promptly formed into highly reactive hydrated formaldehyde that is not under proper biochemical control, as humans alone of all creatures lack a functional cellular defense system.

The responsible enzyme is ADH1, which is at high levels in 20 specific human tissues, notably the cells of the inner walls of blood vessels in the brain and retina, and even the rod and cone cells.

In the brain, formaldehyde is formed inside the cells on the brain tissue side of the blood vessels at the bottom of the brain.

Highly reactive formaldehyde hydrate ( always formed as the dominant molecular configuration when formaldehyde dissolves in water ) has two resonating -OH groups on either side of its single carbon atom, both slightly acidic, so each easily bonds to basic proteins in such a way as to potentially elicit unwanted macrophage attention and potential activation.

This same slightly acidic hydrate of formaldehyde can act on DNA and RNA and certain basic proteins in the cytosol to not only attach but to cross link and thus inactivate them.

This is most likely how formaldehyde, formed inside the blood brain barrier from methanol, causes deactivation of the mitochondrial activity of the eye and other important tissues adjacent to brain blood vessels.

Formaldehyde labeled molecules powerfully attract microglia, monocytes, and macrophages, as the immune system reacts and overreacts.

Myriad scattered spots of inflammation evolve, leading to the complex results that mystify many investigators.

All they need to know is that the initial insult is methanol, and then modern methods can quickly prove this clearly.

In addition, it is essential to appreciate that ethanol is a powerful antidote, as it preempts ADH1 enzyme, preventing the forming of up to 16 times higher molar concentrations of methanol from being formed into formaldehyde.

This is why for many modern chronic diseases, those who drink just one ethanol drink daily have half the harm as those who never drink.

[ recent strong evidence of human cancers… ]

Eva A. Schernhammer cites Woodrow C. Monte methanol-formaldehyde paradigm in brave, cautious Harvard team study that confirms more cancers in aspartame diet soda users over 22 years — full plain text: Rich Murray 2012.10.27
http://rmforall.blogspot.com/2012/10/eva-schernhammer-cites-woodrow-c-monte.html

top MS incidence in Shetland Islands re methanol from smoked foods via wood and peat fires, Prof. WC Monte, While Science Sleeps text 2012 Jan — methanol and formaldehyde in particleboard, plywood, paper factories: Rich Murray 2012.05.15
http://rmforall.blogspot.com/2012/05/top-ms-incidence-in-shetland-islands-re.html
http://health.groups.yahoo.com/group/aspartameNM/message/1648

check out methanol as multiple sclerosis toxin — in humans only, ADH1 enzyme turns it into rampant formaldehyde right inside cells in 20 tissues, the WC Monte paradigm: Rich Murray 2014.06.18
http://rmforall.blogspot.com/2014/06/check-out-methanol-as-multiple.html

smoke from pack cigarettes gives 40 mg methanol for 20 gr tobacco, 6 tobacco methanol papers, Carl Neuberg 1926-1939, Berlin — so methanol formaldehyde toxicity paradigm is co-factor in 18 tobacco diseases — WC Monte gives 23 references: Rich Murray 2013.03.29
http://rmforall.blogspot.com/2013/03/smoke-from-pack-cigarettes-gives-40-mg.html

Methanol (wood alcohol), blood half-life 3 hours, is made in humans only into uncontrolled formaldehyde right inside cells by ADH1 enzyme in 20 specific tissues, the WC Monte paradigm.

Methanol (wood alcohol) is 11% of aspartame — every can of drink gives 22 mg free methanol into the GI tract.

With a blood half-life 3 hours, it reaches and easily enters every cell in the body and fetus every minute.

Ethanol is a potent antidote, blood half-life only 1/3 hour, as it strongly preoccupies ADH1 enzyme, preventing the conversion of methanol into formaldehyde inside cells of 20 human tissues — so this protection is specific evidence of methanol toxicity.

Humans alone of all creatures are uniquely vulnerable.

Formaldehyde modified macromolecules in damaged cells powerfully attract a vigorous immune system response, leading to many scattered micro lesions of inflammation, especially in the inner walls of blood vessels and adjacent tissues.

Since fall, 2007 Prof. Woodrow C. Monte, Arizona State University, Food Science and Nutrition, retired 2004, has given a free online bibliography of 782 mostly full text medical research references:

http://www.whilesciencesleeps.com/references/

Methanol mainly comes from aspartame, cigarette and wood smoke, and unfresh fruits juices and vegetables cut up and preserved wet at room temperature in sealed cans and jars.

Download a free copy of Chapter 9 and have a read

[ 99 pages, including list of all 782 full text online references for book — Chapter 9 has 146 references ]:

Chapter 9 Multiple Sclerosis

http://www.whilesciencesleeps.com/files/While%20Science%20Sleeps%20-%20Chapter%209%20%28Prepublication%20copy%29%20Website%203-15-2012.pdf

Chapter 12 Autism and Other Birth Defects

While%20Science%20Sleeps%20-%20Chapter%2012%20(ref).pdf 651.62 KB

The references are located on his website:

http://www.whilesciencesleeps.com/references/ ,

as are the simple dietary changes that you must follow because your life may depend on it:

http://www.whilesciencesleeps.com/monte-diet/ .

Table 5.2 is the key chart — ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
http://rmforall.blogspot.com/2013/03/table-52-is-key-chart-adh1-enzyme-at.html

California OEHHA sets methanol ingestion level 23 mg daily, same as from 1 can aspartame diet soda, 10 cigarettes, 3 tomatoes, or 4 cans green beans: Rich Murray 2013.07.03
http://rmforall.blogspot.com/2013/07/california-oehha-sets-methanol.html

Citing WC Monte twice, well funded RQ He 3 year study in China shows Alzheimers harm in monkeys from chronic methanol becoming formaldehyde, Part 2/2: Rich Murray 2014.07.27
http://rmforall.blogspot.com/2014/07/citing-wc-monte-twice-well-funded-rq-he.html

diet, mostly aspartame, fruit and soda drinks correlate with depression NIH-AARP Diet and Health Study 11,311 cases depression after 2000 in 263,923 seniors 50-71 who gave beverage use in 1995-6, Honglei Chen team 2014 April: Rich Murray 2014.12.23
http://rmforall.blogspot.com/2014/12/diet-mostly-aspartame-fruit-and-soda.html

Men have several times more ADH1 in their GI tract than women, so less methanol gets into the blood to attack other tissues, so now four times as many women get multiple sclerosis as men.

“While Science Sleeps” textbook, 2012 January:

“Methanol travels easily to breast tissue and has been found in human milk. 219

The cells that produce milk within the breast, cells prone to develop the most common of breast cancers, adenocarcinoma 358, contain high levels of ADH1 enzyme, 358 allowing methanol’s conversion to formaldehyde [ inside the cells as free floating acidic hydrated formaldehyde, highly reactive on both sides of molecule ].

Mammary epithelial cells have no way to protect themselves from formaldehyde 216 — no means to render it harmless.

They, unlike other breast tissue, contain no aldehyde dehydrogenase enzyme (ADH 3) that could transform formaldehyde into the non-carcinogenic formic acid. 216

Of particular interest are recent findings implicating ADH as playing a pivotal role in the formation of breast cancer, documenting a greater incidence of the disease in women with higher levels of ADH1 activity in their breasts. 357”

Many people are protected by ethanol, the potent antidote, in their blood from fermentation by bacteria in the GI tract.

Many of these diseases, including diabetes 2, are twice as harmful for those who never drink ethanol, compared to those who have just one standard drink a day, due to the inhibition by ethanol of formation of formaldehyde from methanol by ADH1.

Formaldehyde from methanol specifically impairs two enzymes in mitochondria that process ATP, shutting down aerobic energy metabolism — causes fatigue, weakness, and also blindness in the retina.

human high levels of ADH1:

liver, kidney, lung;

intima and media (inner walls) of blood vessels, notably base of brain and in retina;

rods and cones in retina;

purkinje cells of vermis in cerebellum;

islets of Langerhans in pancreas;

fibroblasts in skin, bone marrow, synovial tissues in joints;

milk ducts of breast;

major sources of methanol (wood alcohol):

smoke from cigarettes, wood, peat;

aspartame, and chewing gums;

some dark wines and liquors;

fresh tomatoes, black currants;

unfresh fruits juices vegetables, cut up and heated, preserved wet at room temperature in sealed cans jars plastic containers (including home preserves and jugs of apple cider by farming families);

jams jellies marmalades;

smoked fermented spoiled foods;

some fresh coffees;

approved food additive dimethyl dicarbonate;

vehicle fuels;

medical chemical mortuary facilities, home and industry solvents, factories for processed wood and paper products — formaldehyde heated to 150 deg C releases methanol…

Alzheimer’s, multiple sclerosis, atherosclerosis, breast cancer, arthritis, asthma, diabetes, birth defects, autism…

“As a matter of course, every soul citizen of Earth has a priority to quickly find and positively share evidence for healthy and safe food, drink, environment, and society.”

within the fellowship of service,

Rich Murray,
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
1039 Emory Street, Imperial Beach, CA 91932
[email protected]
505-819-7388 cell
619-623-3468 home
http://rmforall.blogspot.com
https://www.facebook.com/rmforall
https://www.facebook.com/rmforallmethanol
https://www.linkedin.com/pub/rich-murray/30/835/652
rich.murray11 free Skype audio, video chat

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