Does anyone have practical advise for dealing with a second cycle of cholestyramine to get Aubagio out of your blood? I am having a very hard time this time. I am on day 8 (of 11) and seriously want to quit. I am very distended, my bowels need a break, everything hurts. I look and feel 15 months pregnant. I completed my first round and then found out my Aubagio level was 50, so I needed to do a complete second round – which I was not emotionally or mentally prepared for. I am taking stool softeners but those aren’t working anymore – I want to finish this and not have to do charcoal treatment. Any help?