Hi there. I began Plegridy July 2015 when I was diagnosed. I chose it for what I thought would be the ease of administering the drug and the slight side effects. I had a second relapse in mid September and had a week in hospital on iv steroids. That relapse has left a marked difference in my walking, sad to say. The flu like symptoms were mild, a couple of Paracetamol sorted them. However, apart from the spectacular red/black injection site reactions that remain for a month or six weeks, for me the deal breaker was the low moods/depression. Bang on cue the day after injection, I would not want to get out of bed. When I eventually did resurrect, I would spend the day weeping for no reason at all. I was very angry too. This would last 2/3 days and then I'd be back to normal. A follow up mri done for comparison, showed no changes, so Plegridy was working. However, for me, those side effects were just too much, and they were avoidable with alternatives. Eventually (after giving it a fair trial for six months, at my Neuro's persuasion) I came off it and went on Tecfidera. My moods returned to normal immediately. The statistics for Tec are much a higher percentage for slowing progression and reducing relapses. I hadn't done enough research when I chose Plegridy. I'm so much happier on Tec. I don't mean to dissuade you, but would like you to be aware of the mood/emotional state.

Thanks a lot for the info, I'll definitely keep it in mind over the next few months!