As I have posted a couple times before about Plegridy I thought I'd follow up 3 injections in.... Just had my first 100% dose on Monday, flu effects lasting a day or so. Not finding it affects me mentally too much (no more than a lack of sleep will do). Toughest thing is really sensitive skin which I guess is due to the drug sitting under the skin and aggravating, hopefully this will reduce as lasts ~a week. Just been running which was a slog, I guess my body is feeling a bit under attack right now so is a little weak. I'm a bit disappointed I've had to prompt for an MRI (surely they need a baseline to compare) against. Have others had similar experiences? Ben