Hi all just wanted to share my experience of being on Avonex injections. I have just done my 9th week of injecting and all is going well with just a few interesting minor things having happened. Learning how to operate the injection pen was quite easy, I was given 3 goes to practice on myself with practice pens on a sponge on my leg while supervised by a nurse who came to my home. Then I did the actual injection. It didn't hurt apart from the very tiny "TING" when the needle goes in... count to ten and then remove the needle/pen from my leg gently and secure it in a special locking cap.. Done. Over these last 9 weeks I have had very slight side effects consisting of a stubborn headache hours after which I keep at bay with Paracetamol, very slight temperature; just felt a tiny bit warmer than usual, again Paracetamol worked on that too, also took some advice from Shift MSers and drink lots of water and eat well too :) . Several weeks ago I decided I would show my daughter how clean and easy my injections were to do but when I pulled out the needle I must have hit a blood vessel going in and blood trickled out and down my leg which was a surprise.. stopped not long after but that was a bit of a shock.. also had a bruise in that spot for the next two weeks. Bit nervous after that one but all has been fine in that respect since. On week 7 after injecting in my left leg I was left with a slight red raised patch at the injection site that was warm to touch and felt solid under the skin but again it had gone back to normal in 2 weeks so was ready to be injected in that leg again (alternate legs used each week..) And apart from having ON the week I started on Avonex (cleared up within two weeks) and having just had a hideous cold for two weeks I have had no major side effects from being on Avonex.. (touch wood..!!). :)