1 week before next Tysabri infusion- sleep and anxiety issues?

Does anyone’s sleep suffer 1 week before their next infusion? 1 week to go and feeling a bit more anxious in the day and I can wake up early. Rather frustrating as I feel ok in between infusions in the main. Taking duloxotine for neuropathic pain and anxiety which really helps but just don’t feel quite right atm. Bit vague I know! Practicing cbt techniques but they don’t always work. Any suggestions?