@Rich1976

Last reply

Rich1976

Plegridy vs avonex

What are the views on these 2 treatments. Appreciate that it is personal but I need to make a decision in the next couple of weeks thanks

shelley44

@shelley44

@rich1976 are they 1st ever treatments . I started with copaxone about 18months all going good . I heard avonex can bring on cold/flu like symptoms ..its hard to pick out 1st one but I'm glad with mine ..

Stumbler

@Stumbler

@rich1976 , Avonex and Plegridy are both interferon-based medications. Both can give temporary flu-like symptoms. However both are "first-line" treatments, i.e. the least effective of the Disease Modifying Therapies (DMTs). The latest thinking is to hit MS hard and fast, with the best treatments. to avoid accumulating damage using less effective treatments. Check out :- https://support.mstrust.org.uk/file/DMD-Book-Final-WEB.pdf ; and https://www.mstrust.org.uk/about-ms/ms-treatments/ms-decisions-aid , to see whether there is a more effective treatment that better suits your lifestyle, then ask your Neuro for it. It's your body that will be accepting these drugs.

Rich1976

@Rich1976

@shelley44 , this is my first treatements. I have been offered Copaxone but I don't really fancy the 3 x per week injections.

Rich1976

@Rich1976

@stumbler - My MS nurse did mentioned the latest thinking but because they think my first 'episode' was over 7 years ago, I can't take part in the study as it is only up to 5 years. I have been offered Ocrelizumab but the MS nurse and Neurologist are suggesting starting a low dose. The Neuro has even suggested that I could if I wanted not have any treatment and see what happens between now and the next MRI. But not many Neuros would advice this. I only have a very small number of lesions with 2/3 of them being possibly linked to MS & so far all the others tests results have been clear. My symptoms have all but gone. Reading some of the others posts, I feel quite luckily but I want to make sure I am taking the right DMT. I have also been told that they have a strict NHS protocol to follow to decide which DMTs I can have.

embroideress

@embroideress

@rich1976 I was offered only first line treatments here in France; only those with ‘aggressive rrms’ can begin with stronger dmts. I started with Plegridy, took it for 7 months but the flu-like symptoms persisted, chills, headache, weakness, and these would last for two days. Also I felt strange, sad and not myself, so the Neuro switched me to Avonex. The injection is easier, doesn’t cause skin reaction. Also, after a few months I have no headache and just a bit of fatigue the next day. But everyone is different, and the big advantage of Plegridy is the every other week injection schedule. I’ll just mention that I had several decades without relapse and began treatment very late, at 57, so I’m also afraid to take a stronger treatment. If you’re younger, then you may want to try for the more effective dmt. Let us know what you decide and how it goes 😀

Stumbler

@Stumbler

@rich1976 , as far as choice of Disease Modifying Therapies (DMTs) are concerned, nothing should be precluded from your choice. It is down to you to make your arguments for the DMT of your choosing. Yes, the hospital may have their protocols, but the basis for their decision may well be the MRI scan, which does not reflect a full picture.....

shelley44

@shelley44

@rich1976 yea I was thinking the same but said I'd try to see how I get on as couldn't bare to have flu like symptoms ..the 3 a week dont bother me now ..best of luck choosing your treatment 🤞