@dannyJ, I have no experience of Gilenya, so cannot comments, and have just received Lem. Maybe someone who has experienced both is better placed to comment, but having had the option of all DMTs, (11 years experience) I opted for the former. It is still early days, and more patience is required on my part prior to hopefully obtaining its benefits. There any many threads on it here, listing its numerous significant potential beneficial effects. I personally believe it has more promise than any other, the reasons why will be evident if you read former posts. However, others have reported faring well with the latter also. There are some who are vociferous in support of Lem, and I'm sure you will hear from them. I am, but somewhat more measured in making bold claims until I am in a position to speak from personal experience and am naturally more cautious in any event. However, the scientific evidence thereon is inpressive! Good luck whichever decision you make. I believe it depends on where you are physically and mentally.

Impressive not in