@Allyson_Wagg

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Allyson_Wagg

Is any one on plegridy

Hi my husband has rrms diagnosed 4 years ago he has started on plegridy just had his third injection yesterday is any one else using plegridy and what side affects do you get he gets the fls within minutes of injecting then feels rough for couple of days would love to hear other people's stories

Stumbler

@Stumbler

Hi @allyson_wagg and welcome. It's good of you to join us on behalf of your husband. Us blokes do like to suffer in silence! It's been a long time since I was on an interferon and getting the flu symptoms. I used to time my shot so that I was already going to bed before the symptoms hit. I'd be OK the following morning. Other members, who should be along soon, use paracetamol and ibuprofen either before and/or after the shot. Here's a couple of earlier conversations on this subject. https://shift.ms/forums/topic/rebif-and-the-infamous-flu-like-symptoms https://shift.ms/forums/topic/dmd-avonex-advice-pls Hopefully these side-effects will wane after a few shots. :wink:

SamanthaThompson

@SamanthaThompson

Hello, I have been taking Plegridy for a couple of months now. I usually take paracetamol beforehand and then after until the next day. I have found it to be good, I was previously on Avonex and was getting terrible muscle pain (injection site). The only downside is it seems to be affecting my tummy, so I have a GP appointment this week to see if I can have something to help. I do feel a bit rough for a few days but I'm sure that is because Plegridy is designed to stay in the body for longer which allows for the less frequent injections. Paracetamol definitely helps me and I make sure I have eaten before I take it. Sometimes I have to add ibuprofen but it's not everytime. I hope your husband gets on okay with it, hopefully the side effects will become more manageable over time (I hope so!) Sam x

Allyson_Wagg

@Allyson_Wagg

Thank you Sam for your reply the fls hit him within minutes of injecting he takes paracetamol before injecting and injects last thing at night hoping to sleep through worse of it did your side affects lesson over time Ally x

SamanthaThompson

@SamanthaThompson

Hi, Yes, I have started to tolerate it better, I've been on the maintenance dose for a while now. The third injection your husband had this week is only the first full dose, so it is probably that, I felt quite wonky after my first full dose! I hope he feels better soon and that the next injection is better for him. Sam x

Allyson_Wagg

@Allyson_Wagg

Thank you Sam hopefully now he's on the full dose his body will start to get used to it Ally x

sigmadelta

@sigmadelta

Well, I've been on Plegridy for 10 months, and have just stopped using it. Frankly, there was no benefit whatsoever. After the first half-dose I felt like death warmed up for 2 days. I hoped things would improve as my body learnt tolerance etc.. However, this did not prove to be the case. It is described as "Flu-like symptoms", which is putting it rather mildly I feel. Sometimes after the injection, I could barely get from my bed to the bathroom, legs had just disappeared from beneath me. This obviously causes a rising sense of panic, which in itself does little for MS. I persevered for 10 months, after each injection I was 5 or 6 days getting over it properly, and then simply counting down to the next one ... and dreading it. I phoned my consultant, and she is happy for me to stop. The worrying thing with beta interferons is the admission that they are not sure what they actually do to the body. But if how I felt after every injection is anything to go by, it is not good. Also with Plegridy, it has no impact on the progression of MS, it simply helps protect against a major attack. MS is a fickle beast, and I daresay others have had a more positive outcome with Plegridy. Personally speaking, (and that's all any of us can do), I found the cons outweighed the pros. Interestingly, I read on another MS site, that whilst Plegridy helps stop the immune cells from attacking the myelin, at the same time it also stops any cells repairing the damage. It does not differentiate. Consequently, if you are also taking any other alternative, or "Off the Radar" treatments, they will have no effect. Sean.